The opening week of the 2025 regular season features spotlight games in Philadelphia, Sao Paulo, Buffalo and Chicago, and oddsmakers generally leaned toward the home teams with the early lines released Wednesday. The Super Bowl champion Philadelphia Eagles are a seven-point favorite over the Dallas Cowboys in the 2025 Kickoff Game, and the Pittsburgh Steelers are road favorites against the New York Jets in the only game with a point total under 40 in Week 1. Here's a full rundown of 2025 odds (courtesy of FanDuel) for all games scheduled Sept. 4-8: Thursday, Sept. 4 Dallas Cowboys at Philadelphia Eagles (-6.5) 8:20 p.m. ET on NBC, Lincoln Financial Field, Philadelphia Money line: Eagles -330, Cowboys +265 Total: 46.5 points Friday, Sept. 5 Kansas City Chiefs (-2.5) vs. Los Angeles Chargers 8 p.m. ET on YouTube, Corinthians Arena, Sao Paulo Money line: Chiefs -142, Chargers +120 Total: 44.5 points Sunday, Sept. 7 New York Giants at Washington Commanders (-7) 1 p.m. ET, Northwest Stadium, Landover, Md. Money line: Commanders -350, Giants +280 Total: 45.5 points Tampa Bay Buccaneers (-1.5) at Atlanta Falcons 1 p.m. ET, Mercedes-Benz Stadium, Atlanta Money line: Buccaneers -126, Falcons +108 Total: 48.5 points Carolina Panthers at Jacksonville Jaguars (-2.5) 1 p.m. ET, EverBank Stadium, Jacksonville Money line: Jaguars -144, Panthers +122 Total: 46.5 points Miami Dolphins at Indianapolis Colts (-1) 1 p.m. ET, Lucas Oil Stadium, Indianapolis Money line: Dolphins -104, Colts -116 Total: 45.5 points Las Vegas Raiders at New England Patriots (-2) 1 p.m. ET, Gillette Stadium, Foxborough, Mass. Money line: Patriots -156, Raiders +132 Total: 43.5 points Pittsburgh Steelers (-3) at New York Jets 1 p.m. ET, MetLife Stadium, East Rutherford, N.J. Money line: Steelers -156, Jets +132 Total: 39.5 points Cincinnati Bengals (-5.5) at Cleveland Browns 1 p.m. ET, Huntington Bank Field, Cleveland Money line: Bengals -240, Browns +198 Total: 45.5 points Arizona Cardinals (-4.5) at New Orleans Saints 1 p.m. ET, Caesars Superdome, New Orleans Money line: Cardinals -200, Saints +168 Total: 41.5 points San Francisco 49ers (-1.5) at Seattle Seahawks 4:05 p.m. ET, Lumen Field, Seattle Money line: 49ers -124, Seahawks +106 Total: 45.5 points Tennessee Titans at Denver Broncos (-7) 4:05 p.m. ET, Empower Field at Mile High, Denver Money line: Broncos -350, Titans +280 Total: 41.5 points Detroit Lions (-1.5) at Green Bay Packers 4:25 p.m. ET, Lambeau Field, Green Bay, Wis. Money line: Lions -122, Packers +104 Total: 49.5 points Houston Texans at Los Angeles Rams (-2.5) 4:25 p.m. ET, Sofi Stadium, Inglewood, Calif. Money line: Rams -146, Texans +124 Total: 46.5 points Baltimore Ravens at Buffalo Bills (-1.5) 8:20 p.m. ET on NBC, Highmark Stadium, Orchard Park, N.Y. Money line: Bills -122, Ravens +104 Total: 51.5 points Monday, Sept. 8 Minnesota Vikings (-1.5) at Chicago Bears 8:15 p.m. ET on ESPN/ABC, Soldier Field, Chicago Money line: Vikings -110, Bears -106 Total: 45.5 points --Field Level Media